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Post ssri sexual dysfunction lexapro withdrawal

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Data Based Medicine Americas Ltd. The undersigned submits this petition to request the Commissioner of Food and Drugs to immediately require the addition of boxed warnings, warnings, precautions, and highlights of prescribing information to the product label for all selective serotonin reuptake inhibitor SSRI and serotonin-norepinephrine reuptake inhibitor SNRI products, including branded and generic formulations.

These include, but are not limited to, citalopram Celexadesvenlafaxine Pristiqduloxetine Cymbaltaescitalopram Lexaprofluoxetine Prozacparoxetine Paxilsertraline Zoloftvenlafaxine Effexorand vortioxetine Trintellix.

Require the immediate revision of all SSRI and SNRI product labels including branded and generic formulations to warn of serious and severe risks, as follows:. This was first established in healthy volunteer phase 1 trials in the s. Current product labeling warns of disturbances to sexual functioning, but these warnings are insufficient.

The ability of a serotonin reuptake inhibitor to reduce genital sensation was identified as Post ssri sexual dysfunction lexapro withdrawal back as A study investigated the use of clomipramine as a possible treatment for premature ejaculation [ 1 ]. Neurophysiological testing was used to assess penile sensory threshold before and after treatment.

While clomipramine is classed as a tricyclic antidepressant, it is a potent serotonin reuptake inhibitor. The current was then decreased until it could no longer be perceived. This second figure was taken as a measurement of penile sensory threshold. The study found that the drug had increased penile sensory threshold from Ina similar Post ssri sexual dysfunction lexapro withdrawal involving fluoxetine found an increase in penile sensory threshold from 4.

The fluoxetine study also had the benefit of a control group placebo for whom penile sensory threshold remained unchanged. In addition, there were multiple case reports of genital anesthesia during the s linked to each of the major SSRIs [ 3—9 ], including one that involved reduced nipple sensitivity [ 8 ].

These date from toand involve the use of fluoxetine, sertraline, and paroxetine. Clinical experience suggests that almost everyone who takes an SSRI or SNRI experiences a degree of reduced genital sensitivity, often occurring within 30 minutes of taking the first dose. In this sense, almost everyone taking a serotonin reuptake inhibitor has altered sexual functioning.

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